Analytical Instrument Documents

Lithium ion secondary batteries using spinel-type lithium titanium oxide (LTO) as the negative electrode material are excellent in safety and cycle characteristics due to their chemical stability, and have already been put into practical use.

In comparison with the UltraCOOL probe, SuperCOOL probe represents a cryogenic probe with high sensitivity at lower cost and power consumption. Thermal noise reduction due to new designed cooling system greatly enhances the sensitivity of NMR measurement.

It is often difficult to unambiguously determine structures of molecules, which have many non-protonated carbon atoms. Because such compounds contain quaternary carbons, lack protons and bonding to quaternary carbons each other, HMBC (Heteronuclear Multiple Bond Correlation) experiment cannot provide long-range 1H-13C connectivity. Therefore, INADEQUATE (Incredible Natural Abundance DoublE QUAntum Transfer Experiment), which is 13C-13C correlation experiment at natural 13C abundance, represents a powerful tool for proton-diluted compounds.

Here, we combine ED and solid-state NMR through the first principle quantum computation with the NMR crystallography approach for crystalline structure solution. The method, electron and NMR nano-crystallography, can be applied to nano- to micro-crystals even for mixture samples.

Solid state NMR is a powerful tool to obtain information in the crystalline state which would be lost in the solution state.

The low oral bioavailability of a drug due to its poor aqueous solubility is a major challenge for pharmaceutical development. Solid dispersion (SD), where the amorphous drug is dispersed into the polymer matrix, is one of the useful approaches to improve the aqueous solubility. However, thermodynamically unstable nature of an amorphous drug increases its susceptibility to recrystallize upon storage, which, in turn, reduces its solubility and dissolution. Therefore, design of thermodynamically stable SD is required.

15N NMR is widely used because of the importance of nitrogen in chemistry, materials, biology, environment, etc. However, very low abundance of 15N (<0.4%) results in poor sensitivity and thus makes observation time-consuming. On the other hand, the rest of nitrogen atoms are also NMR sensitive nucleus of 14N. Despite the high abundance of 14N (>99%), it's application is rather limited due to the huge quadrupolar interactions and its spin quantum number I = 1.

JEOL AUTOMAS probe combined with Auto Sample Changer and Auto Tune Unit allows for fully automated solid NMR measurements including sample load/eject, tuning and matching, magic angle spinning frequency control, and temperature control. This enables you to manage efficient data collection as liquid NMR.

We can supply 2.5, 3.2 or 4.0 mm XY-MAS probes suitable for inorganic materials. The XY-MAS probe has two rf channels which enable simultaneous strong rf-field irradiation.

Fluorine and nitrogen containing organic compounds are often found in a variety of fields such as pharmaceutical and material sciences. Such compounds show unique properties based on their conformations and orientations, which are often induced by hydrogen bonds between N-H and F atoms. Therefore, analysis of molecular conformations and inter-molecular interactions are important. Here, we report 14N decoupled 1H-19F HETCOR as an example of hydrogen bonds analysis between N-H and F for fluorinated benzanilide as a demonstration.