Analytical Instrument Documents

Disclaimer: These data are for informational use only. No guarantees are made for the accuracy of the data presented.

Disclaimer: These data are for informational use only. No guarantees are made for the accuracy of the data presented.

Disclaimer: These data are for informational use only. No guarantees are made for the accuracy of the data presented.

Disclaimer: These data are for informational use only. No guarantees are made for the accuracy of the data presented.

Disclaimer: These data are for informational use only. No guarantees are made for the accuracy of the data presented.

Disclaimer: These data are for informational use only. No guarantees are made for the accuracy of the data presented.

Disclaimer: These data are for informational use only. No guarantees are made for the accuracy of the data presented.

It has been a decade since Dodonov and his colleagues first announced the electrospray ionization time-of-flight mass spectrometer (ESI-TOF MS). Their initial findings have been enhanced by Standing and others, and it has been recently reported that a large TOF MS system achieved a mass resolution exceeding 10,000.

Mass spectrometers are commonly combined with separation devices such as gas chromatographs (GC) and liquid chromatographs (LC). The GC or LC separates the components in a mixture, and the components are introduced, one by one, into the mass spectrometer. MS/MS is an analogous technique where the first-stage separation device is another mass spectrometer.

Accurate mass measurements are frequently used to determine the elemental composition for molecular and fragment ions. These measurements are normally obtained by acquiring a high resolution mass spectrum so that the masses are measured for a single species and not measured for unresolved or partially resolved peaks.