Analytical Instrument Documents

A comprehensive description and demonstration of contouring data with Level Tool.

How to acquire and process HMBC spectra: loading high-resolution projections, Level Tool, plotting, understanding HMBC, data interpretation.

How to acquire and process multiplicity-edited HSQC spectra: phasing 2D data, loading high-resolution projections, setting contrast colors in Level Tool, plotting, HMQC versus HSQC, data interpretation.

How to acquire and process COSY spectra: process lists in nD Processor, loading high-resolution projections into 2D Viewer, Level Tool, using Cursor mode to highlight coupling partners, plotting, 1D proton versus 2D COSY, data interpretation, common COSY sequence variants.

How to acquire and process HETCOR and HMQC spectra: loading high- resolution projections into 2D Viewer, Level Tool, plotting, understanding inverse experiments, HETCOR versus HMQC, data interpretation, normal versus inverse probe geometries.

How to acquire and process Carbon and DEPT135 spectra: Drag-and-Drop, manual 1D phasing, using Data Slate to display multiple spectra, plotting, why DEPT135?, data interpretation.

Fluorine is increasingly being used in many new drugs. Fluorine is now appearing in illicit and illegal synthetic drugs. Fluoro Polymers are important to everyday life, for example PTFE (Teflon™).

NMR Probe for Fluorine NMR. What is needed is a Robust Routine HFX NMR Probe that can do every routine experiment well! Including all HFX experiments, 1H{19F}, 19F{1H}, 13C{1H,19F} & X{1H,19F}.

The JEOL ROYAL HFX NMR probe is the world’s first liquid NMR probe switchable between single tune and dual tune mode on the High Frequency coil without compromising the NMR performance. The ROYAL HFX probe operating in single tune mode has the same sensitivity and pulse width performance as the standard ROYAL NMR probe.

Fluorine is found with an ever-increasing frequency in materials science and both legal and illicit drugs [ref 1-5]. In this application note results are presented to illustrate the simplification afforded by the routine application of triple-resonance NMR to clearly assign voriconazole, a molecule containing proton, carbon, and nitrogen molecules with many atoms exhibiting J-coupling to fluorine. The HFX ROYAL probe is a completely new probe technology utilizing magnetic coupling to afford highly efficient HF-X tuning which can function as a simple switch to highest sensitivity dedicated 1H or 19F or very well balanced dual 1H/19F performance on demand. References 6-8 detail the technological developments for the HFX ROYAL probe.