Analysis of Biological Fluids
The AccuTOF-DART can detect a variety of substances in biological fluids such as urine, blood, and saliva with little or no sample preparation. These substances include drugs, amino acids, lipids, and metabolites.
Urine samples were analyzed by dipping a melting point tube in urine and placing the sample in front of the DART ion source. Figure 1 shows positive-ion DART mass spectra of a urine sample from a subject taking ranitidine to reduce stomach acid production. The enlarged view in the inset shows the ranitidine metabolites desmethyl ranitidine and ranitidine N-oxide.