The ROYALPROBE™ HFX can simultaneously irradiate ¹H, ¹⁹F, and ¹³C (or other X-nuclei) even in a basic console with basic two-channel console, and is a versatile probe that can measure a wide-variety of nuclei at high sensitivity. Here we introduce some useful experiments for fluorine-containing compounds that can be run on conjunction with JNM-ECZ400S equipped with ROYALPROBE™ HFX.