Fraction base-KMD plots for a high-MW - S3000 - MSTips - 283
High molecular weight polymers are often MS-silent due to their inherent high dispersity (DM) or detected in the high mass range with low resolving power. An "on-plate" alkaline degradation has thus been developed as a sample pre-treatment on the MALDI target with tenths of ng of polymer to cut long industrial polyester chains into short oligomers amenable to MALDI-HRMS.